Management of Severe Plasmodium Falciparum Malaria in Adults. A Review of National and Regional Guidelines and their adherence to WHO guidelines

Abstract 
 Background: the most prevalent and pathogenic malaria parasite associated with severe illness death is Plasmodium falciparum. In non-endemic countries like Russian federation, P. falciparum a relatively rare but potentially fatal disease found in travelers returning from high burden.
 Aims: this review aims to analyze recommendations for managing different World Health Organization (WHO) endemic regions considered their adherence WHO guidelines.
 Materials methods: we identified highest number of indigenous cases four search treatment guidelines using databases.
 Results: intravenous artesunate mainstay malaria. Mefloquine or fansidar was not indicated reviewed as. Most lack mechanism referring patients malaria, between levels health facilities specific criteria intensive care unit admission.
 Conclusions: mefloquine artemisinin - combination products containing should be used caution cerebral due neuropsychiatric cognitive complications. Understanding how clinical practice areadopted epidemiological settings will help contextualize value validity